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KMID : 1094020170340020119
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Journal of Veterinary Clinics
2017 Volume.34 No. 2 p.119 ~ p.122
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Treatment of Calcinosis Cutis with Minocycline in Five Dogs
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Cho Dae-Hee
Lee Wang-Hui
Park Seong-Jun
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Abstract
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Calcinosis cutis is a chronic condition characterized by insoluble calcified deposits in the skin and subcutaneous tissue. Although there is no uniformly effective treatment for calcinosis cutis, minocycline therapy has demonstrated varying degrees of benefit in humans. Five client-owned dogs with calcinosis cutis were included. Minocycline was administered orally in a dose of 10 mg/kg bodyweight twice a day. Treatment was repeated every day until complete remission. The efficacy of minocycline was evaluated within this period. The side effects of minocycline were monitored and reported by the owners and veterinarians. Of the 5 dogs with calcinosis cutis, which was classified as the dystrophic form, four dogs had a complete remission of calcinosis cutis and one dog had a partial response. The major improvement was a reduction in the size of the calcified deposits and reduction in inflammation associated with them. The duration of remission was 9.1 ± 2.2 weeks. The adverse effects, observed in one dog, were anorexia and vomiting. Minocycline may be effective in the control of calcinosis cutis in dogs.
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KEYWORD
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dog , calcinosis cutis , minocycline , treatment
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